血脂异常患者血清神经鞘磷脂的测定及其意义

Determination and significance of serums sphingomyelin levels in patieats with dyslipidemia

目的:评价血脂异常患者血清神经鞘磷脂(SM)水平。方法:将血脂异常的患者分为总胆固醇(TC)升高组、三酯酰甘油(TG)升高组、低密度脂蛋白胆固醇(LDL-C)升高组和高密度脂蛋白胆固醇(HDL-C)降低组,与对照组SM水平比较。酶法测定SM、TC、TG、LDL-C、HDL-C。用单因素方差分析,Dunnett检验处理数据。结果:血脂异常患者SM水平与对照组比较有显著性差异(P<0.05);TC、LDL-C升高组SM水平与对照组比较有显著性差异(P<0.05),TG升高组、HDL-C降低组SM水平与对照组比较有极显著性差异(P<0.01)。结论:血清SM水平和已知的致动脉粥样硬化危险因子密切相关,提示SM可能是导致动脉粥样硬化发生的重要因素。

Objective： To evaluate the serume sphingomyelin （SM） levels in dyslipidemia patieats. Methods： The dyslipidemia patients were divided into 4 groups： total cholesterol （TC） increased ; triglycerides （TG） increased ; low denseity lipopeotein cholesterol （ LDL - C increased ; and high denseity lipopeotein cholesterol （ HDL - C） decreased. A group of health subjects with normal serum lipids were used as the control group. The SM level were measured by an enzyme method and the values were compared between different dyslipidemia group and the control one respectively . TC, TG, LDL - C and HDL - C were also determined by enzyme method, the data of which was dealt with Dunnett. Results： ANOVA. showed that the patients groups were significantly different from the control one （ P 〈 0.05）. Dunnett test showed that patients with higher TC , TG and LDL - C and lower HDL - C levels had higher levels of SM , compared to control group （P〈0.05 , P〈0.01 , P〈0.05 and P〈0.01, respectively. Conclusion： The serums SM levels are closely related with the known atherogenic risk factors, and they are also an important risk for atherosclerosis.