乳腺癌组织中胰岛素样生长因子结合蛋白-2的表达及其与雌激素受体、孕激素受体相关性的研究

Expression of IGFBP-2 and its correlation with estrogen receptor, progesterone receptor in breast cancer

目的研究胰岛素样生长因子结合蛋白-2(IGFBP-2)在乳腺癌组织中的表达,探讨其与乳腺癌临床病理学特征的关系及与雌激素受体(ER)、孕激素受体(PR)的相关性。方法用免疫组织化学SP法检测42例乳腺癌患者肿瘤组织中IGFBP-2和ER、PR的表达水平。结果在不同大小原发灶、年龄和类型乳腺癌组织中IGFBP-2的表达率无显著差异(P>0.05);IGFBP-2在有淋巴结转移乳腺癌中的表达显著高于无淋巴结转移乳腺癌(P<0.05)。IGFBP-2与ER在乳腺癌中的表达呈中度正相关(P<0.01,rs=0.486);与PR在乳腺癌中表达无明显相关性(P>0.05,rs=0.271)。结论IGFBP-2的表达在乳腺癌的发展和侵袭转移可能起重要作用,并与ER在乳腺癌中的表达呈正相关,提示IGFBP-2的高表达可能是乳腺癌预后不良的指标之一,对乳腺癌的临床治疗有一定的指导作用。

AIM： To investigate the expression of insulin-like growth factor binding protein-2 （IGFBP-2） in breast cancer and its connection with clinical pathological characteristics of breast cancer as well as the correlation between IGFBP-2 expression and estrogen receptor （ER） and progesterone receptor （PR）. METHODS： Examined the expression of IGFBP-2, ER and PR in 42 cases of the breast carcinomas with the immunohistochemical technique （S-P method）. RESULTS： There was no significant difference between the primary tumor extension, age and category in breast cancer （ P 〉 0.05） ; the positive percentage of IGFBP-2 was statistically higher in breast cancer with metastasis in lymph node than those without metastasis in lymph node （ P 〈 0.05）. The expression of IGFBP-2 in breast cancer is midrange positive correlation with that of ER （ P 〈 0.01, rs = 0.486）, and it is not connected with expression of PR in breast cancer （ P 〉 0.05, rs = 0.271 ）. CONCLUSION： The expression of IGFBP-2 may play an important role in the progression, invasion and metastasis of breast cancer, and there is a positive correlation between the expression of IGFBP-2 and ER in breast cancer. It demonstrates that over expression of IGFBP-2 may be a reference to evaluate unfavourable prognosis of breast cancer.