壳-芯电纺超细纤维作为药物释放载体的研究

Core-shell ultrafine electrospun fibers for drug release applications

应用同轴共纺技术制备了以L-型聚乳酸为壳层材料,盐酸四环素为主要芯质材料的壳-芯超细纤维膜,研究了这种超细纤维膜的微观结构、力学性能与药物释放特性.结果表明,药物能够包覆在一层很薄的可降解聚合物壳层中,形成一种储库型药物释放系统.纤维的直径大小对纤维膜的各项理化性能有较大影响.随壳层聚合物浓度升高,纤维的平均直径增大,力学强度降低.药物能够从纤维膜中持续释放出来.这种壳-芯超细纤维有望用于药物释放、载药缝合线和医用敷料等生物医学领域.

The ultrafine fiber mats were fabricated by coaxial electrospinning in which poly （L-lactic acid） （PLEA） and tetracycline hydrochloride （TCH） were used as the shell and the core materials, respectively. These eleetrospun fibers were characterized using scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, and tensile testing. The in vitro drug release behavior was also examined. The results show that a reservoir-like drug release system can be conveniently obtained through encapsulating TCH into the PLEA ultrafine fibers. The diameters of the resulting fibers have an significant effect on their physical-chemical properties. Furthermore, a sustained TCH release from these fiber mats was also observed. Consequently, the core-shell ultrafine fibers containing drugs may be used as drug release carriers or made into biomedical devices such as sutures and wound dressings.