用反应停和雷公藤多甙联合治疗白塞病50例疗效观察

Clinical analysis of 50 cases of Behcet disease treated by thalidomide combined with tripterygium glycosides

目的:观察反应停和雷公藤多甙联合治疗白塞病的疗效。方法:对1995～2004年间50例确诊白塞病患者进行了回顾性研究,分析其发病情况、初发部位、临床表现、实验室检查、病理检查及治疗情况。结果:白塞病以男性多见,好发于青壮年,初发部位以口腔多见,全身多个器官系统均可受累,但以口腔、生殖器、皮肤、眼和关节常见,针刺反应对白塞病特异性较高。26例采用反应停和雷公藤多甙联合治疗,24例采用左旋咪唑对照治疗。反应停和雷公藤多甙组取得显著效果(P<0.01)。结论:白塞病的临床谱广,诊断主要依靠临床表现,针刺反应阳性有辅助诊断意义。反应停和雷公藤多甙治疗效果显著。

Objective：To analyse the clinical characteristics and to study the effects of thalidomide combined with tripterygium glycosides in the treatment of Behcet disease. Methods：50 cases of Behcet disease were analysed retrospectively. 26 of them were treated by thalidomide at 35 mg combined with tripterygium glycosides at 10 mg 3 times a day. 24 cases were treated by levamisole at 50 mg 3 times a day with 3-day-treatment and 11-day-interval. All the patients were treated for 2 months. Results： Middle-aged male patients with chronic onset were common, oral ulcer was the first common symptom. The disease could damage all organs, however the oral mucosa, skin,oculus, genitalia and joint were commonly involved. Reaction of needle puncture was highly specific in the diagnosis. The effective ratio of treatment was observed in 92% of the patients treated by the combination of thalidomide with tripterygium glycosides and in 67% of those by levamisole. Conclusion：The clinical manifestations of Behcet disease are complex, its diagnosis mainly depends on symptoms and signs, reaction of needle puncture is helpful in diagnosis. Thalidomide combined with tripterygium glycosides is effective in the treatment of the disease.