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阿德福韦在慢性乙型肝炎中的研究进展

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摘要 研究表明,如果能有效地抑制乙型肝炎病毒（HBV）的复制,就有可能减缓或停止慢性乙型肝炎（CHB）患者的疾病进展,改善患者的预后.干扰素虽然具有调节免疫功能、抗病毒的双重功效,但不良反应较多,疗效也不尽人意.核苷类药物拉米夫定是乙肝抗病毒治疗中的一个里程碑,疗效确切,耐受性和安全性良好;然而长期应用可导致患者产生耐拉米夫定HBV变异株,出现肝功能及病毒学指标的反复,甚至可能发生肝功能衰竭.阿德福韦作为一种新的抗HBV感染的核苷酸类似物已于2002年9月经美国食品药品管理局（FDA）批准在美国上市,在我国也已完成Ⅲ期临床试验,目前正式上市.现就阿德福韦在CHB中的研究应用作一综述.
作者 韩硬海 王云玲 曹祥梦
机构地区 山东省东营市胜利石油管理局胜利医院感染科
出处 《上海医学》 CAS CSCD 北大核心 2006年第9期673-677,共5页 Shanghai Medical Journal
关键词 慢性乙型肝炎 阿德福韦 美国食品药品管理局 乙型肝炎病毒(HBV) 抗病毒治疗 耐拉米夫定 肝功能衰竭 调节免疫功能
分类号 R512.62 [医药卫生—内科学]
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参考文献29

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上海医学
2006年 第9期

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