原发性肝癌患者血清肝纤维化指标检测的意义

The Significance of The Measurement of Serum Fibrosis Markers in Liver Fibrosis for The Hepatocellular Carcinoma

目的探讨原发性肝癌血清肝纤维化指标检测的意义。方法采用ELISA法检测58例原发性肝癌、35例转移性肝癌、41例肝外恶性肿瘤患者血清HA、PcⅢ、LN和Ⅳ-C含量并与AFP作相关分析。结果原发性肝癌组HA、PcⅢ、LN和Ⅳ-C水平明显高于转移性肝癌组和肝外恶性肿瘤组(P<0.05或0.01)。AFP与HA、PcⅢ、LN和Ⅳ-C呈明显的正相关(γ分别为0.68、0.55、0.73、0.53,P<0.05)。结论肝纤维化指标与原发性肝癌关系密切,血清肝纤维化指标检测对原发性肝癌肝纤维化程度的判断、鉴别转移性肝癌有一定的价值。

Objective To study the significance of the measurement of serum fibrosis markers in liver fibrosis for the hepatocellular carcinoma. Methods The levels of the serum hyaluronlc acid, protein collagen Ⅲ, layer fibronectin and collagen Ⅳ were measured by methods of ELISA, in 58 patients with hepatocellular carcinoma, 35 patients with transitivity liver cancer and 41 patients with cancer out liver, the levels of the serum alpha-fetoprotein（AFP）were also measured ,they were analyzed relatively. Results The levels of hyaluronic acid, protein collagen Ⅲ, layer fibronectin and collagen Ⅳ of the hepatocellular carcinoma groups higher than the transitivity liver cancer a groups and cancer out liver groups（P 〈0.05 or 0.01 ）. AFP were correlation with hyaluronic acid, protein collagen Ⅲ ,layer fibronectin and collagen Ⅳ （γ = 0.68,0.55,0.73,0.53, P 〈 0.05 ）. Conclusion The serum fibrosis markers in liver fibrosis were relativity nearly with the hepatocellular carcinoma, there are values that estimate the liver fibrosis for the hepatocellular carcinoma and differentiate the transitivity liver cancer.