小儿支气管炎颗粒药效学研究

A pharmacodynamic study on the drug of Child Bronchitis Grains

目的：观察小儿支气管炎颗粒的抑菌、抗炎及止咳、化痰作用。方法：采用体外抑菌试验方法来评价该药对试验中引起呼吸道感染的细菌的抑制或杀灭作用；通过对小鼠致炎、致咳及对气管酚红排泌的作用来观察其抗炎、止咳、化痰的作用。结果：体外抑菌试验显示，该药对引起呼吸道感染的细菌有较好的抑制或杀灭作用，MIC范围均在0，25～64mg／mL之间，MIC50大多为4～16mg／mL，其中对金黄色葡萄球菌、表皮葡萄球菌及肺炎克雷伯杆菌的作用较强，对普通变形杆菌及绿脓杆菌也有一定的抑制作用，但作用较弱。对二甲苯所引起的小鼠耳廓肿胀具有明显的抑制作用；对小鼠氨水引咳有明显延长引咳潜伏期并明显减少小鼠咳嗽次数的作用；对小鼠气管酚红排泌有明显的促进作用。结论：小儿支气管炎颗粒具有较明显的抗菌消炎、止咳化痰的作用。

Objective： To study the effect of the Child Bronchitis Grains on baeteriostasis, anti-inflammation, cough-stopping and phlegm-dissipating. Method： The effect of the drug in bacteriostasis in RTI was assessed by the way of out-of-body bacteriostasis test. And the effect of the Child Bronchitis Grains was observed on bacteriostasis, anti-inflammation, cough-stopping and phlegm-dissipating in the inflammatory and coughing rats by the excreting and secreting phenol red secretion experiment. Results： The experiment manifested that medicine was effective in bacteriostasis in RTI, the MIC scope was between 0.25～64 mg/mL, MIC50 mostly in the 4～16mg/mL, most effective in killing staphylococcus aureus. staphylococci, and klebsiella pneumoniaeto and also effective on proteus vulgaris and blu-pus bacillus. It could repress obviously the swelling ear of small rat caused by dimethyl benzene, extend the cough incubation with ammonia water, reduce the number of coughing times of the small rat and promote the small rat excreting and secreting phenol red secretion obviously. Conclusions： The Child Bronchitis Grain has obvious effect on antiinflammation, stopping coughing and phlegm-dissipating.