氨茶碱预防极低出生体重儿呼吸暂停的临床观察

A clinical observation of aminophylline in preventing the apnea of very low birth weight infant

目的:探讨氨茶碱预防极低出生体重儿呼吸暂停的临床疗效。方法:126例极低出生体重儿,随机分为观察组及对照组各63例。观察组于未发生呼吸暂停前即予氨茶碱预防性治疗,并与对照组进行比较。结果:呼吸暂停发生率:出生10天观察组11.11%,对照组49.29%(χ2=19.93,P<0.001);胎龄36周时观察组14.29%,对照组58.73%(χ2=24.96,P<0.001),差异均有统计学意义。在吸氧时间、体重增至2 kg平均日龄、平均住院日方面,两组比较差异有统计学意义(P<0.05)。结论:极低出生体重儿预防性应用氨茶碱,能降低呼吸暂停的发生,减少吸氧时间,有利体重增加及缩短住院天数。

Objective： To explore the clinical efficacy of aminophylline in preventing the apnea of very low birth weight infant. Methods： 126 premature infants of very low birth weight were randomly divided into control group and prevent group, each with 63 infants. The infants of prevent group were treated preventively with aminophylline before they apnea phenomenon happened to them, and compare them with the control group at the same time. Results： Originating rate of apnea： After bern 10 days the infants of prevent group was 11.11%, the control group was 49.29% （χ^2= 19.93, P 〈 0.001 ）. At the time of gestafional age of 36 weeks, the originating rate of apnea of the prevent group was 14.29% and that of the control one was 58.73 % （χ^2=24.96, P 〈 0.001 ）. The differences between these two groups have statistic significance. At the aspect of inhale oxygen time, time that weight added to 2 kg and average days in hospital, and all the differences have statistic significance （ t = 10.89, P 〈 0.001 ; t = 2.04, P 〈 0.05; t = 3.28, P 〈 0.05）. Conclusions： The application of aminophylline to very low birth weight infant can reduce the frequency of apnea, reduce the inhale oxygen time, help put on weight and curtail time in hospital.