还原型谷胱甘肽治疗小儿白血病化疗致肝损害的疗效分析

The observation of the treatment of Reduced Glutathion in liver injury from chemotherapy to childhood leukemia

目的:探讨还原型谷胱甘肽治疗白血病患儿化疗致肝功能损害的效果。方法:将87例诊断明确且排除病毒性肝炎的白血病患儿随机分为两组:治疗组46例,对照组41例。两组患儿均口服维生素C、肝泰乐,治疗组给予还原型谷胱甘肽30 mg/(kg.次)静脉滴注,1次/d;对照组给予甘草酸二铵3 mg/(kg.次)静脉滴注,1次/d。7 d后复查肝功能。结果:治疗后两组肝功能均有不同程度的改善,治疗组优于对照组;治疗组和对照组有效率分别为84.8%和68.3%,两组比较差异有统计学意义。结论:还原型谷胱甘肽对白血病患儿化疗致肝功能损害有较好的防治作用。

Objective： To explore the effects of Reduced Glutathion in liver injury from chemotherapy of childhood leukemia patients. Methods： 87 childhood leukemia patients with such liver injury with viral hepatitis ruled out were randomly divided into two groups. There were 46 cases in treatment group, which treated with Reduced Glutathion, and other 41 cases were in control group, which treated with Diammonium Glycyrrhizinate. The patients in both groups all had Vitamine C and Glucurone. Then the changes of liver functions were observed after 7 days. Results：After treatments, the liver functions of all the patients were meliorated in different degrees. Among them the melioration of treatment group was significantly better than that of control group. The total rate of treatment group was 84.8 % and the total rate of control group was 68.3 %. And there was a significant difference between them. Conclusions： Reduced Glutathion has markedly effects in treating liver injury resulting from chemotherapy to childhood leukemia patients.