小儿急性药源性肌张力不全77例分析

Analysis of the acute drug-induced dystonias in 77 children

目的：分析小儿急性药源性肌张力不全常见原因、临床表现，并提出相应的预防和治疗方法。方法：对1999年～2005年发病较重而入院的小儿急性肌张力不全病因、常见药物、临床表现和治疗方法进行分析，总结其教训和经验。结果：引起小儿急性药源性肌张力不全的常见药物依次为甲氧氯普胺、氟哌啶醇、奋乃静、五氟利多、感冒冲剂等。结论：急性药源性肌张力不全易在小儿中发生，临床医生应提高警惕，同时也要引起家长重视，不可乱服或误服药物。

Objective： To analyze the possible reasons and the clinical characteristics of acute drug-induced dystonia in children and to find out more effective prevention and treatment. Methods： A retrospective analysis was made on the records of children with acute drug-induced dystonia from 1999 to 2005, including analysis of the causes, clinical features, prevention and treatment. Results： The medicines, which caused the chil- dren acute drug-induced dystonia were metoclopramide, haloperidol, perphenazine, penfluridol, and then the cold powder in turn. Conclusions： The children with acute dystonia induced by misuse of dugs are not uncommon in clinic. Doctors should pay more attention to it and teach their parents general knowledge about this disease.