水性巴布剂基质配方研究

Study on Matrix of Hydrophilic Cataplasm

目的:研究以卡波姆和聚丙烯酸钠作为水性巴布剂基质的最优配方。方法:通过正交设计实验,以配方中卡波姆、聚丙烯酸钠、PVPK30、CMCNa、PVA为因素,以用量为水平,设计L18(37)正交表,以内聚力、剥离强度作为考察指标。结果:配方中各因素对内聚力的作用大小依次为卡波姆、CMCNa、PVA,对剥离强度的作用大小依次为卡波姆、PVPK30、聚丙烯酸钠。结论:巴布剂基质的最优配方为卡波姆:聚丙烯酸钠:PVPK30∶CMCNa∶PVA=3．0∶4．0∶0．5∶0．2∶0．5。

Objective： To optimize the matrix of hydrophilic cataplasm. Method： Content of carbomer, sodium polyacrylate, PVPK30, CMCNa and PVA were screened with adhesion strength and cohesive strength as indices by L18 （3^7 ） orthogonal design. Result： Results showed that adhesion strength could be affected by the contents of carbomer, CMCNa and PVA with order of carbomer 〉 CMCNa 〉 PVA（ P 〈 0, 05 ） , and cohesive strength could be affected by the contents of earbomer, PVPK30 and sodium polyaerylate with order of earbomer 〉 PVPK30 〉 sodium polyaerylate（ P 〈 0.05 ）. Conclusion： The best formula of hydrophilic cataplasm matrix could be earbomer： sodium polyacrylate： PVPK30： CMCNa： PVA = 3.0： 4.0： 0.5： 0.2： 0.5.