黄芪对高脂血症小鼠血脂及脂质过氧化的影响

Effects of Astragalus on serum lipids and lipoperoxidation in experimental hyper lipidemic mice

[目的]探讨黄芪对高脂血症小鼠血脂及脂质过氧化的影响.[方法]取小鼠随机分组,除正常组外的其他组小鼠灌胃给予脂肪乳剂,建立高脂血症小鼠模型,分别灌胃给予不同剂量黄芪组小鼠18.0,9.0,4.5 g/kg黄芪水提取物,连续4周,测定各组小鼠血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)含量,谷胱甘肽过氧化物酶(GSH-Px)和超氧化化物歧化酶(SOD)活性,脂质过氧化物(LPO)含量.[结果]不同剂量黄芪组小鼠血清TC,TG,LDL-C含量明显下降,SOD,GSH-Px活性明显增强,血清LPO含量明显下降.[结论]黄芪具有调节小鼠血脂代谢及增强机体抗脂质过氧化的作用.

OBJECTIVE To investigate the effects of Astragalus on serum lipids and lipoperoxidation in experimental hyperlipidemic mice. METHODS The mice were randomly divided, and apart from the mice in normal group, all the mice in other groups were fed with lipid emulsion for 4 weeks. After the in experimental hyper lipidemic mice were succeed, different dosages of experimental control groups in which the mice were treated with Astragalus at dosages of 18.0, 9.0, 4.5 g/kg respectively. After 4 weeks, the TC, TG, HDL-C, LDL-C, SOD, GSH-Px and LPO in serum were measured. RESULTS Astragalus could significantly decrease the serum TC, TG, HDL-C in the experimental hyperlipidemic mice, and markedly increased the level of serum HDL-C. Mean level of serum LPO in the experimental groups treated by Astragalus at different dosages were much lower than that in hyper lipidema group, and the SOD and GSH-Px activities of serum in the group of Astragalus were much higher than those in hyper lipidema group. CONCLUSION Astragalus can regulate lipid metabolism, enhance the antioxidation and reduce the lipid peroxidation in mice with hyperlipidemia