早产儿血与胃液中促胃液素、胃动素的相关性研究

The dependability of gastrin and motilin in blood and gastric juice in premature infants.

目的动态监测早产儿生后第1、第3、第7天血、胃液中促胃液素(GAS)、胃动素(MOT)水平,并予以非营养性吸吮(NNS)干预,探讨早产儿血、胃液中GAS、MOT的动态变化及相关性。方法需经间断鼻胃管喂养(INGF)早产适于胎龄儿60例,根据是否辅以NNS,随机分成无非营养性吸吮(N-NNS)组及NNS组;并以同期出生无窒息、无消化系统结构及功能异常足月新生儿25例为对照。放射免疫法(RIA)批量检测血及胃液GAS,MOT水平。结果1血及胃液中GAS,MOT水平分别呈直线正相关。2N-NNS组及NNS组血及胃液GAS,MOT水平均低于对照组;第1天N-NNS组、NNS组血GAS、血及胃液MOT与对照组比较;差异有显著意义(P<0.05);第3天N-NNS组及NNS组血GAS,MOT低于对照组,差异有统计学意义(P<0.05);N-NNS组血GAS低于NNS组,差异有显著意义(P<0.05);第7天N-NNS组血GAS、MOT均低于NNS组及对照组,差异有显著意义(P<0.05)。结论血及胃液中GAS,MOT水平分别呈直线相关。早产儿血及胃液中GAS,MOT水平低于足月儿,NNS能促进GAS,MOT分泌。

Objective To study the variation and dependability of gastrin and motilin in blood and that in gastric juice and the correlation between the changes of these two after intervention by monitoring the levels of gastrin and motilin in blood and that in gastric juice in premature infants and intervening with non-nutritive sucking （NNS）. Methods 60 appropriate for gestational age, premature infants who accepted intermittent nasogastric feeding（INGF） were randomly assigned into a non-NNS group and NNS group according to NNS. 25 normal full-term infants were enrolled as controls. The gastrin and motilin in blood and gastric juice were detected by radioimmunoassay（RIA）. Results The gastrin and motilin in gastric juice positively correlated with those in blood. The levels of gastrin and motilin in blood and gastric juice in N-NNS and NNS groups on the first, third and seventh day were lower than those of the control group; There were significantly statistical difference of gastrin in blood and motilin in blood and gastric juice between N-NNS and NNS groups and the control group on the first day （P〈0.05）. The gastrin and motilin in blood in N-NNS and NNS groups were lower than those of the control group on the third day （P〈0.05）; The gastrin in blood of N-NNS group was significantly lower than that of NNS group （P〈 0.05）. The levels of gastrin and motilin in blood in N-NNS were significantly lower than those of control group and NNS group on the seventh day （P〈0. 05）. Conclusions The gastrin and motilin in gastric juice positively are related to those of gastrin and motilin in blood. The gastrin and motilin in blood and gastric juice in premature infants are lower than those of full-term infants and are closely related to the functional disturbances of gastrointestinal tract. NNS could increase the secretion of gastrin and motilin.