甘利欣联合退黄汤治疗肝内胆汁淤积症临床分析

Clinical study on the treatment of combination of Tuihuang Tang and Diammonium Glycyrrhizinate on intrahepatic cholestasis

目的:观察甘利欣注射液(甘草酸二铵)联合活血化瘀退黄汤治疗肝内胆汁淤积症的临床疗效。方法:将86例患者随机分为两组,治疗组46例采用甘利欣注射液联合活血化瘀退黄汤治疗,对照组40例给予甘利欣注射液静滴,两组均应用一般护肝治疗;观察比较两组疗效,两组主要症状、血清总胆红素(TBil)及丙氨酸氨基转移酶(ALT)的变化。结果:治疗组临床疗效、主要症状及TBil和ALT的改善均优于对照组(P<0.05)。结论:甘利欣注射液联合活血化瘀退黄汤治疗肝内胆汁淤积症有较好疗效。

Objective To observe the therapeutic Tuihuang Tang on intrahepatic cholestasis. Methods integrated effects of diammonium glycyrrhizinate combined with 86 cases were divided into two groups randomly,the group （n=46） and control group （n=40）.The control group was treated with diammonium glycyrrhizinate. The integrated group was treated with diammonium glycyrrhizinte and traditional Chinese medicine. The two groups were treated on the basis of the same general treatment. Results The total effective rate in the integrated group was obviously higher than that in control group（P〈0.05）. After treatment the serum alanine aminotransferase （ALT） and serum total bilirubin （TBil） decreased significantly in the integrated group （P〈0.05）. Conclusion The combination of traditional Chinese and diammonium glycyrrhizinate is effective and safe in the treatment for intrahepatic cholestasis.