摘要
We evaluated,employing a logistic regression model,the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients(57 males;mean age,52.9 years;range,20-78 years)with chronic hepatitis C virus(HCV)from Rosario,Argentina.HCV was confirmed by ELISA and PCR.H.pylori status was determined by ELISA.Of the 106 patients evaluated,47(44.3%)had cirrhosis.A total of 70.2%(33/47)of cirrhotic patients and 47.5%(28/59)of noncirrhotic patients were H.pylori-positive.In univariate analyses,cirrhosis was associated with age(P = 0.016)and H.pylori-positive status(P = 0.019)but not with gender(P = 0.28)or length of infection(P = 0.35).In multivariate analysis,H.pylori infection(P = 0.037;OR = 2.42;95%CI = 1.06-5.53)and age(P = 0.033;OR = 1.04;95%CI = 1.00-1.07)of patients remained significant and independently associated with cirrhosis.In conclusion,our results demonstrate an association between H.pylori infection and cirrhosis in patients-with hepatitisC virus.
We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients （57 males; mean age, 52.9 years; range, 20 -78 years） with chronic hepatitis C virus （HCV） from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 （44.3%） had cirrhosis. A total of 70. 2% （33/47） of cirrhotic patients and 47.5% （28/59） of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age （P= 0. 016） and H. pylori-positive status （P = 0. 019） but not with gender （P = 0.28） or length of infection （P = 0.35）. In multivariate analysis, H. pylori infection （P = 0. 037; OR = 2.42; 95% CI=1.06-5.53） and age （P = 0.033; OR = 1.04; 95% CI = 1.00-1.07） of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H.
