乳腺癌患者血清微量元素测定的临床价值

Clinical Value of Determination of Trace Elements in Serum in Breast Cancer

目的:探讨9种血清微量元素与乳腺癌的关系。方法:采用原子吸收分光光谱法对61例健康妇女、78例乳腺癌手术前及61例乳腺癌手术后血清中铜(Cu)、铁(Fe)、锌(Zn)、锰(Mn)、铅(Pb)、铬(Cr)、镉(Cd)、镍(Ni)、钼(Mo)9种微量元素的含量进行测定。结果:3组血清中的微量元素含量有显著差异,其中血清Fe、Cu、Zn、Mn含量乳癌组明显高于健康对照组,血清Fe、Zn、Cu、Ni含量乳腺癌术前组明显高于乳腺癌术后组(P<0.01),血清Cu/Zn比值乳腺癌组高于健康对照组。结论:结果提示Fe、Zn、Cu、Mn、Ni可能是乳癌的危险因素,Mo可能为乳癌的保护因素。

Objective：To study the relation between trace elements in serum and breast cancer. Methods：In 61 healthy women and 61 patients with breast cancer, the levels of nine trace elements including Cu, Fe,Zn, Mn, Pb, Cr, Cd,Ni and Mo were determined. Results：There was significant difference in the levels of trace elements among groups. Compared with control group, the levels of Fe,Cu,Zn, Mn and Cu/Zn was higher in breast cancer group. The levels of Fe, Zn, Cu and Ni in preoperation group was higher than those in postoperation group （P〈0.01）. Conclusion：The results indicate that Fe, Zn,Cu, Mn and Ni may be risk factors of breast cancer, Mo may be prective factor of breast cancer.