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基因MMP-2、PTEN和Fn的表达与胃癌临床病理因素的关系 被引量：1

Relationship Between Genes MMP-2,PTEN,Fn and the Clinicopathological Factors in Gastric Cancer
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摘要 为了探讨基因MMP-2、PTEN和FN与胃癌临床病理因素的关系,采用免疫组织化学方法,检测了56例胃癌中MMP-2、PTEN和Fn的表达.结果表明:MMP-2、PTEN的阳性表达和Fn的异常表达分别为58.9%、55.4%和60.7%.低分化癌中MMP-2的表达和Fn的异常高于高分化癌(P<0.05).MMP-2的表达和Fn的异常与胃癌浸润深度、淋巴结转移正相关(P<0.05),PTEN的表达与淋巴结转移负相反(P<0.05).MMP-2和PTEN的表达呈负相关(P<0.05),MMP-2表达和Fn的异常呈正相关(P<0.01),PTEN表达与Fn异常之间无明显相关性(P>0.5).通过该研究发现,检测胃癌组织中MMP-2、PTEN和Fn的表达,有助于了解胃癌的发展和评估胃癌患者的预后. In order to explore the relationship between genes MMP-2, PTEN, Fn and the clinicopathological factors in gastric cancer, the expression of MMP-2, PTEN and Fn were investigated in 56 cases of gastric cancer tissues bv immunohistological method. The results indicated that, in gastric cancer, the expression of MMP-2, PTEN and abnomal Fn were 58.9%, 55.4% and 60. 7% respectively . The expression rates of MMP-2 and abnomal Fn were higher in poor differentiated cancer than that in well differented cancer（ P〈 0.05） . The expression of MMP-2 and abnomal Fn correlated positively to the invasion depth, lymph node metastasis（P〈0.05）, the expression of PTEN correlated negatively to lymph node metastasis（ P 〈 0.05） . There was a negative relationship between the expression of MMP-2 and PTEN , and a positive relationship between the expression of MMP-2 and Fn , and no relationship between the expression of PTEN and Fn. Results showed that the expression of MMP-2, PTEN and Fn in gastric cancer can help us to understand the development of gastric cancer and patient＇s prognosis.
作者 雷振东 赵华 雷三林 段伦喜
机构地区 中南大学湘雅二医院普外科
出处 《生命科学研究》 CAS CSCD 2006年第3期265-269,共5页 Life Science Research
关键词 胃癌 MMP-2基因 PTEN基因 Fn基因 gastric cancer MMP-2 PTEN Fn
分类号 R735.2 [医药卫生—肿瘤]
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参考文献9

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共引文献50

同被引文献6

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生命科学研究
2006年 第3期

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