川芎嗪注射液对急性微循环障碍大鼠淋巴循环的影响

Effects of Ligustrazine Injection on Lymph Circulation in Rats with Acute Microcirculation Disturbance

目的:探讨川芎嗪注射液(LI)对急性微循环障碍(AMD)大鼠淋巴循环的干预作用。方法:W istar雄性大鼠16只,分成LI组和NS组。采用颈静脉注射Dextran 500方法复制AMD模型并通过淋巴学方法,观察LI对AMD大鼠淋巴循环的干预作用。结果:在AMD时,肠系膜淋巴管(ML)收缩性、肠淋巴流量、淋巴细胞输出量明显降低,淋巴液中有少量单核细胞,并且淋巴液粘度较高。经LI治疗后,ML收缩性、肠淋巴流量、淋巴细胞输出量显著升高,淋巴液中有大量单核细胞出现,淋巴液粘度明显降低,与对照组比较有显著性差异(P<0.05)。结论:川芎嗪可能通过增强淋巴管转运功能、降低淋巴液粘度的作用,影响AMD的转归。

Objective： To explore the interferential effect of ligustrazine injection （LI） on lymph circulation in rats with acute microeireulation disturbance （AMD）. Methods： Sixteen Wistar male rats were divided into experimental and control groups. AMD was done by Dextran 500 injection from jugular vein and effects of LI on lymph circulation were observed in these rats by lymphatology methods. Results： During AMD phase, the contractility of mesenteric lymphatic （ML） , the intestinal lymph flux, lymphoeytes out put were obviously decreased, and there was little monocytes in the lymph fluid, but the lymph fluid viscosity was increased. After treatment of LI, the contractility of ML, the intestinal lymph flux, lymphocytes out put was obvious increased. There was a lot of monocytes in the lymph fluid and the lymph fluid viscosity was decreased. There were signifeant difference compared with control group （ P 〈 0.05 ）. Conclusion ： LI can influence the recovery of AMD though enhancing the contractility of ML and the transport function of lymph circulation and decreasing lymph fluid viscosity.