有氧运动对糖尿病患者T细胞亚群及血清sIL-2R水平影响的研究

Research on the Effect of Aerobic Exercise on T-cell Subsets and Level of Serum sIL-2R With Diabetes

选择年龄31～55岁的Ⅱ型糖尿病患者，38人为实验对象。同时选取同龄的健康男性22人作为对照，抽取静脉血进行CD4＋、CD8＋及sIL-2R检查。指导糖尿病患者进行12周的有氧运动，其中32人顺利完成运动后再次抽取静脉血进行CD4＋、CD8＋及血清sIL-2R检查。结果：与对照组相比运动前糖尿病患者CD4＋、CD8＋无明显改变，但CD4＋／CD8＋明显降低，血清sIL-2R值明显升高。12周有氧运动完成后，糖尿病患者CD4＋／CD8＋比值明显升高而血清SIL-2R值明显降低。结论：有氧运动可能通过提高CD4＋／CD8＋比值并降低血清sIL-2R水平来改善糖尿病患者的细胞免疫功能。

Methods： 38 subjects of 2 diabetes men aged 31 - 35 are assigned to 12 weeks of aerobic exercise training. 22 normal men of the same age are assigned as control group and draw blood to test CD4 ＋, CD8 ＋ and sIL -2R before and after instructing the patients to do 12 - week aerobic exercise training of 32 patients who complete the exercise. Results： Comparing with control group, the CD4 ＋ , CD8 ＋ of type 2 diabetes do not change obviously, but the CD4 ＋/CD8 ＋ ratios decreased and serum SIL- 2R decreased obviously. After 12 -week exercise training, the level of the plasma sIL-2R decreased and CD4 ＋/CD8 ＋ ratios increased in patients with type 2 diabetes. Conclusion： the aerobic exercise can improve the function of cell - mediated immunity of type 2 diabetes through decreasing the level of serum sIL- 2R and increasing CD4 ＋/CD8 ＋ ratios.