妇女分娩前后血浆血小板激活因子水平的变化

The Change in Plasma Levels of Platelet-activating Factor before and after Delivery

采用生物分析法检测妇女孕３８周和分娩后１ｈ血浆血小板激活因子（ＰＡＦ）的水平，以了解分娩前后母体ＰＡＦ水平的变化及其与妊娠高血压综合征（妊高征）的潜在关系。结果：正常妊娠组孕３８周的ＰＡＦ活性为（２５．００±５．６５）μｇ／Ｌ，显著高于轻中度妊高征组［（１４．７４±４．５６）μｇ／Ｌ］和重度好高征组［（１１．４５±６．０８）μｇ／Ｌ］（均为Ｐ＜０．０５）。三组孕妇分娩后１ｈ的ＰＡＦ活性分别为（３３．９０±４．１２）、（３２．２８±５．９３）和（３５．９３±１０．８３）μｇ／Ｌ，均显著高于同组孕３８周的水平（均为Ｐ＜０．０５）。结果提示，血小板激活因子可能参与好高征的发病机制，而胎盘在血小板激活因子的代谢调节中具有重要的地位。

The levels of platelet-activating factor(PAF)in plasma sampled firstly on the 38 week in gestation and secondly within 1 h after placenta expulsion were investigated aiming at exploring the change in PAF levels before and after delivery and its relation to pregnancy-induced hypertension(PIH).Subjects were grouped into normotensive pregnancy,mild and moderate PIH(MM PIH) and severe PIH (SPIH).A bioassay was used to evaluate the activity of PAF in plasma. Results showed that the activity of PAF in normotensive pregnancy was(25.00±5.65)μg/L, significantly higher than that of MM PIH[(14.74±4. 56)μg/L] and SPIH[(11.45±6.08)μg/L],(P<0.05).After delivery, the activities of PAF in these three groups were(33.90±4.12),(32.28±5.93) and(35.93±10.83)μg/L,respectively, apparently higher than those before labor.These results suggested that PAF,the important bioactive lipomediator, might be involved in the pathological mechanism of PIH.The role of placenta in the metabolic regulation of PAF was also discussed.