龙脑基β-二酮铁配合物催化的苯乙烯类化合物的不对称环氧化反应

Asymmetric Epoxidation of Styrene Analogues Catalyzed by Camphyl (β-Diketone)-iron Complexes

合成了四个龙脑基β-二酮Fe(III)络合物,并用它来催化苯乙烯类化合物在氧气和2-乙基丁醛作用下的不对称环氧化反应.在25～30℃下,反应获得较高的化学产率,得到的手性环氧化合物的ee范围为47.5%～91.6%.考察了催化剂结构、底物结构、反应温度等因素对反应的化学产率和光学收率的影响.

Four camphyl β-diketone iron（Ⅲ） complexes were synthesized and used in the asymmetric epoxidation of styrene analogues affording the corresponding epoxides in good chemical yields and enantioselectivities in the range of 47.5%-91.6% ee with combined use of molecular oxygen and 2-ethylbutyraldehyde as sacrificial aldehyde at 25-30 ℃. Some factors influencing yield and enantioselectivity were discussed.