cAMP反应序列结合蛋白及其家族与转录调节

Transcriptional Regualtion by CREB and Proteins of CREB Family

ｃＡＭＰ反应序列结合蛋白（ｃＡＭＰ－ｒｅｓｐｏｎｓｉｖｅｅｌｅｍｅｎｔｂｉｎｄｉｎｇｐｒｏｔｅｉｎ，ＣＲＥＢ）经磷酸化激活后，可参与ｃＡＭＰ诱导的多种靶基因的转录调控。新近研究表明，ＣＲＥＢ的转录调节作用可能是通过ＣＲＥＢ结合蛋白（ＣＲＥＢ－ｂｉｎｄｉｎｇｐｒｏｔｅｉｎ，ＣＢＰ）实现的。在神经系统中，ＣＲＥＢ可能介导神经递质诱导的基因表达，并能通过放大神经营养因子的信号，参与神经细胞增殖、分化、存活等生物效应。

CREB(cAMP-responsive element binding protein),which can be activated after phosphorylation by protein kinase A,plays an important role in cAMP-induced grne expression.Several recent studies have suggested that a co-activator designated as CREB binding protein(CBP)is crucial in mediating the transcriptional activity of CREB.In nervous system,in addition to playing a role in neurotransmitter-induced gene transcription,CREB may take part in mediating neurotrophin signals that ultimately lead to such cellular responses as proliferation, differentiation and survival.