急性低氧对血浆皮质醇浓度及海马去甲肾上腺素含量的影响

EFFECT OF ACUTE HYPOXIA ON THE CHANGE OF HIPPOCAMPAL NE CONTENT AND PLASMA CORTISOL LEVEL

本工作观察不同氧浓度（２１％，１０．４％及７．９％Ｏ＿２）、不同低氧时间猫血浆皮质醇浓度和海马内去甲肾上腺素（ＮＥ）含量的改变，以分析海马在低氧应激过程中的作用。结果显示，吸入１０．４％及７．９％Ｏ＿２后，猫血浆皮质醇浓度逐渐升高，分别于４５ｍｉｎ及３０ｍｉｎ达峰值；而低氧３０ｍｉｎ后，海马组织中的ＮＥ含量明显降低；两者与低氧程度无明显关系。结果提示，急性低氧性应激可致血浆皮质醇浓度的升高和海马脑区ＮＥ递质含量的降低。

The effect of acute hypoxia on the changes of plasma cortisol level and hippocampus NE level of cat during inhalation of 21 %, 10. 4 % or 7. 9 % O2 were investigated.It was found that both 10. 4 % and 7. 9% O2 inhalation caused a gradual increase in plasma cortisol level reaching a plateau in 30-45 min time. While the contents of NE in VHIP and DHIP showed significant decrease 30 min after hypoxia. The degree of both these changes are not related to the hypoxic level of the inhaled O2. The results show that acute hypoxic stress would induce some increase in plasma cortisol level and some decrease in hippocampus NE content.