冠心病患者脉搏波流速的研究

Artery distensibility of patients with coronary artery disease

目的研究冠心病患者脉搏波流速(PWV)特点及临床意义。方法住院患者行冠状动脉造影,根据冠状动脉病变程度进行分组。所有患者同时测定脉搏波流速(PWV)。结果冠状动脉造影阳性151例,其中冠状动脉单支病变组68例,2支病变组51例,3支病变组32例,冠状动脉造影无明显狭窄的对照组87例。研究对象4个组的PWV分别为(11.66±2.14)mm/ms、(12.38±2.01)mm/ms、(12.59±2.24)mm/ms和(9.83±0.99)mm/ms,差异有统计学意义,P<0.05。将冠状动脉病变程度、脉压高低、收缩压值、舒张压值、年龄大小、有否糖尿病病史、有否高血压病史、血脂是否异常、性别、吸烟、饮酒、体重指数与PWV进行多元逐步回归分析,冠心病多支病变、脉压高、年龄大、有糖尿病史为PWV增大的独立的危险因素(P<0.05)。结论冠状动脉病变程度越重,PWV越大。多支病变、年龄大、脉压高和糖尿病是PWV增大的危险因素。

Objective To analyze artery distensibility and its clinical significance of the patients with coronary artery disease. Methods All patients performed coronary angiography and the measurement of pulse wave velocity （PWV）. Results There were 68 cases of one coronary artery stenosis group,51 cases of two coronary artery stenosis group, 32 cases of 3 coronary artery stenosis group, 87 cases of no coronary artery stenosis as control group, and their PWVs were （11.66±2.14）mm/ ms, （ 12.38±2.01 ）mm/ms, （ 12.59±2.24）ram/ms and （ 9.83±0.99 ）mm/ms separately,and had significant difference （P〈0.05）. After muhifactor logistic regression, lesion degrees of coronary artery, age, pulse pressure and diabetes were independent predictors of PWV. Condusion The were severe the coronary artery lesion was, the greater the pulse wave velocity was, The aged, large pulse pressure, diabetes and multiple coronary artery stenosis were independent predictors of great PWV.