急性冠状动脉综合征患者血清超敏C-反应蛋白水平变化及其影响因素

Changes and relevant influence factors of high sensitivity C-reactive protein of patients with acute coronary syndrome

目的探讨急性冠状动脉综合征(ACS)患者血清超敏C-反应蛋白(hsCRP)和心肌肌钙蛋白I(cTnI)变化及其影响因素。方法①采用化学发光免疫分析法检测50例ACS患者、20例OMI患者和20名健康人的hsCRP和cTnI含量。②以hsCRP为因变量,以年龄、性别、高血压史、糖尿病史、吸烟史、cTnI、甘油三酯(TG)、胆固醇(CHO)、载脂蛋白A(APOA)、载脂蛋白B(APOB)、血糖(GLU)、高密度脂蛋白胆固醇(HDL-C)、尿酸(URI)为自变量进行多元逐步回归分析。结果①ACS组的hsCRP、cTnI均高于OMI组和对照组(P<0.05);OMI组的hsCRP、cTnI水平与对照组相比有升高趋势,但差别无统计学意义(P>0.05)。②以hsCRP作为因变量的多元逐步回归方程式为:hsCRP=-3.362+0.02446X7+1.097X9(X7为cTnI,X9为CHO,X7、X9显著性均为P<0.01)。结论ACS患者血清hsCRP、cTnI水平明显升高;血清hsCRP水平和cTnI、CHO呈正相关。

Objective To investigate the relationship between serum high sensitivity C-reactive protein （hsCRP）, Cardiac Troponin I（cTnI ） and the incidence of major cardiac events of the patients with acute coronary syndrome（ACS）, the levels of serum hsCRP and cTnI were detected 8-12 h after acute chest pain in the patients with ACS. Methods （1）hsCRP,cTnI were measured by way of a chemiluminescence immunoassay. （2）The affecting factors of age,gender,history of hypertension, diabetes mellitus,history of smoking,cTnI,TG,CHO,APOA,APOB,GLU,HDL-C and URI were analynized in a Multiple Stepwise Regression model with the hsCRP as the dependent variable. Results （1）Serum hsCRP and cTnI were higher in the ACS group than that in the OMI and Control group （P〈0.05）. The hsCRP and cTnI in the OMI group were higher than that in the control group,but no statistical significance （P〉0.05）. （2）The Multiple Stepwise Regression equation was： hsCRP=-3.362 ＋0.02446X7 ＋ 1.097X9 （ X7 ： cTnI, X9 ： CHO, P〈0.01 ）.It suggested that hsCRP is positively associated with cTnI and CHO. Conclusion Serum hsCRP,cTnI are significantly higher in the ACS group than those in the OMI and control group （P〈0.05）. Serum hsCRP of the ACS group is positively related with cTnI and CHO.