血清瘦素水平与冠心病的关系

The relationship between the level of serum leptin and coronary heart disease

目的探讨冠心病患者与非冠心病患者之间血清瘦素水平的差异及血清瘦素与血脂、C-反应蛋白(CRP)的相关性。方法所有被研究者共100例,分为冠心病组与非冠心病组两组。受检者过夜禁食14h,于清晨空腹卧位抽取肘静脉血,测定胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇,同时离心分离血清,置-20℃冰箱保存备用,集中测定瘦素及CRP。结果①冠心病组的血清瘦素水平明显高于非冠心病组[(8.84±4.99)ng/ml和(5.81±3.30)ng/ml,P<0.05];②冠心病组与非冠心病组血清血脂、CRP水平差别无统计学意义(P>0.05);③血清瘦素水平与血脂、CRP间无明显相关性。结论血清瘦素与冠心病的发病明显相关。血清瘦素水平可作为预测冠心病的独立危险因素。

Objective To study the difference of the level of serum leptin between coronary heart disease （CHD） and non-CHD group. To study the relationship among the level of the leptin, lipid andCRP. To explore the possible mechanism of leptin led to CHD. Methods I00 cases were divided into two groups as CHD group and non-CHD group. All the patients starved for 14 hours and the vein blood was sampled morning. The blood samples were tested the cholesterol, triglyceride, high dense lipoprotein cholesterol and low dense lipoprotein cholesterol. At the same time , the serum was centrifugally separated and saved in -20 ℃ refrigerator to measure the leptin and CRP. Results （1） The leptin level in CHD group was obviously higher than the normal group（P〈0.01 ）. （2） The CRP and lipid level in CHD group had no difference with the non-CHD group（P〉0.05 ）. （3） There was no relationship among the leptin, CRP and the lipid level. Conclusion （1）There are very clearly relationship between the leptin level and CHD. （2）The leptin level is the independent factor to detect the danger of CHD. （3）The mechanism of leptin causes CHD need further studied.