p73、p63和p53基因在人非小细胞肺癌组织中的表达

The expression of p73,p63 and p53 gene in non-small cell lung carcinoma and their relations with the prognosis

目的:探讨p73、p63和p53在非小细胞肺癌(NSCLC)的表达及与预后的关系。方法:免疫组化法测定93例NSCLC p73、p63和p5的表达并对其与年龄、性别、吸烟、病理类型、组织分化等因素进行统计学分析。结果:p53、p63和p73在正常肺组织表达阳性率分别为25%、25%和12·5%,在NSCLC的表达阳性率分别为65·6%、54·8%和71%,差异有显著性(P<0·05)。p53表达阳性率与淋巴结转移相关(P<0·05);p6表达阳性率与肺癌的组织类型和淋巴结转移有关(P<0·05);肺鳞癌组织p63随分化程度降低表达增强(P<0·05)。结论:p53、p63和p73均参与了NSCLC的发展、浸润和转移,可作为了解NSCLC的生物学行为和判断预后的指标。

Objective： To explore the expression and relations with prognosis of p53, p63 and p73 in non-small cell lung cancer（NSCLC）, Methods： The expression of p53 ,p63 and p73 in 93 cases of NSCLC were checked by Immunohistochemistry. The relations with the expression of p53, p63 and p73 and the multiple factors of age,gender,smoking, pat hological type,differentiation, stage, lymph node metastasis and survival time were analyzed statistically. Results： The expression rates of p53, p63 and p73 in normal lung tissue sections were 25%, 25% and 12.5%, respectively, and the expression rates of p53 ,p63 and p73 in the 93 NSCLC were 65.6% ,54.8% and 71% ,respectively（P〈0.05）. The expression of p53 was associated with lympha node metastasis（P〈0. 05）. The expression of p63 was associated with lympha node metastasis and pathological type（P〈0.05）, The expression rates of p63 in squamous cells lung cancer were highly expressed along with lower histological differentiation. Conclusions： p53, p63 and p73 contribute to the development,invasion and metastasis of NSCLC, which suggested to know the biological behavior and judge the prognosis of NSCLC.