转化生长因子-β1在结直肠癌中的表达及与预后的关系

Study on expression of transforming growth factorβ1 in human colorectal carcinoma and its correlation with prognosis

目的探讨转化生长因子（TGF）-β1在结直肠癌中的表达水平及与预后的关系。方法应用免疫组化技术检测52例结直肠癌病例术后标本巾TGF-β1表达水平与血管内皮生长凶子（VEGF）及临床病理特征间的相关性，Log-rank时序检验TGF61蛋白表达与生存时间的关系。结果TGF-β1表达为阴性和阳性者分别有11例和41例，而VEGF表达为阴性和阳性者分别有14例和38例，两者间有显著相关性（X^2=0．633，P〈0．01），TGF-β1表达与Dukes分期（X^2=19．866，P〈0．01）、淋巴结转移情况（X^2=13．152，P〈0．01）也显著相关。本组病例总的3年生存率为49．1％，而TGF61表达为阴性和阳性者的3年生存率分别为69．2％和20．5％（X^2=11．64，P〈0．01）。结论TGF-β1表达水平是影响结直肠癌患者预后的重要因素，临床上作为判断患者预后指标值得进一步研究。

Objective To investigate the expression of transforming growth factor β1（TGF-β1） in human colorectal carcinoma and its value for predicting the prognosis. Methods The expression of TGF-β1 and vascular endothelial growth factor（VEGF） was measured in specimens of 52 colorectal cancers by immunohistochemistry. The features of clinical pathology were analyzed and the follow up of all patients were conducted. The correlation between the expression of TGF-β1 and the survival time was studied with Log-rank test. Results Of 52 patients, no expression of TGF-β1 and VEGF was observed in 11 and 14 patients, and the expression was noticed in 41 and 38 patients, respectively. There was a significant positive correlation between expression of TGF-β1 and expression of VEGF（X^2 =0. 633, P〈0. 01）. Furthermore, the expression of TGF-β1 was significantly correlated with Dukes staging （X^2= 19. 866, P〈 0.01） and metastasis of lymph nodes（X^2 =13. 152, P〈0.01）. The 3-year overall survival rates（OSR） in all patients was 49. 1% and the 3 year OSR of patients with and without expression of TGF-β1 were 20. 5% and 69. 2% respectively（X^2 =11.64, P=0. 0006）. Conclusion The expression of TGF-β1 could be served as an important predicator for prognosis of colorectal carcinoma.