2型糖尿病大血管病变与超敏C反应蛋白及脂联素相关性研究

Association of ultrasensitive C-reactive protein and adiponectin and macrovascular complications in patients with type 2diabetes mellitus

目的分析2型糖尿病(DM)合并大血管及无大血管病变与血清超敏CRP及脂联素水平相关性。方法采用酶联免疫法测定受试者血清超敏CRP水平,用放射免疫法测定血清脂联素水平,同时测定体重指数(BMI)、血压、血脂等指标。结果2型DM大血管病变组超敏CRP明显高于无大血管病变组和正常对照组(均P<0.01),DM无大血管病变组高于正常对照组(P<0.01);2型DM大血管病变组脂联素水平明显低于DM无大血管病变组和正常对照组(P<0.05或P<0.01)。多元逐步回归分析提示血清hs-CRP与脂联素有高度相关性(P<0.01)。结论CRP可能是2型DM和2型DM大血管病变的危险因子。脂联素具有延缓和抑制糖尿病大血管病变的作用。

Objective To explore the association of ultrasensitive C-reactive protein（U-CRP） and adiponectin and macrovascular complications in patients with type 2diabetes mellitus（DM）. Methods The level of serumU-CRP was tested by en- zymeqinked immunosurbent assay（ELISA）, and the level of serum adiponectin was tested by radio immunosurbent assay, body mass index（BMI） ,blood pressure,serum lipid were tested at the same time. Results The level of U-CRP in group of type 2 DM with macrovascular complications（G3） was significantly higher than the group without macrovascular complications（G2） and control group（G1）,the level of U-CRP in G2 was higher than G1. The level of adiponectin in G3 was significantly lower than G2 and G1. multivariate stepwide regression analysis shown there was association of the serum U-CRP and adiponectin（ P 〈0.01）. Conclusion The level of U-CRP might be a risk factor of macrovascular complications in patients with type 2diabetes mellitus . the adiponectin can delay and inhibite it.