大黄治疗颅脑损伤致急性肾功能衰竭的临床研究

Effect of Rhubarb in Head InJured Patients with Acute Renal Failure

目的 探讨大黄对颅脑损伤致急性肾功能衰竭的治疗作用及安全性。方法 选择颅脑损伤致急性肾功能衰竭患者106例，随机分为观察组和对照组各53例。对照组予常规系统治疗；观察组在对照组治疗的基础上加用大黄治疗。结果 治疗1～36d呼吸和心律异常平均出现例次、平均颅内压（ICP）、血浆BUN平均水平和平均最高水平、同为血透治疗时平均需要血透治疗次数观察组低于对照组（P〈0．001），多尿期出现时间、尿常规正常（血尿、尿蛋白、尿红细胞及潜血消失）时间观察组早于对照组（P〈0．001）；血浆Cr平均水平、平均最高水平观察组低于对照组（P〈0．005）；应激性溃疡出现率、需要血透治疗例数、无效率观察组低于对照组，显效率、总有效率观察组高于对照组（P〈0．05）；观察组在大黄治疗期间及停药后均未发现明显的不良反应。结论 大黄用于颅脑损伤急性肾功能衰竭的救治，疗效可靠，使用安全。

Objective To study the effect and security of rhubarb in the treatment of acute renal failure（ARF） caused by head injury. Methods 106 head injured patients with acute renal failure were randomly divided into treatment group （53 cases） and control group （53 cases）. Control group were given traditional system treatment;while the rhubarb were added to therapeutic group. Results The level of R,HR,ICP,BUN and the average cases of hemodialysis in the therapeutic group were significantly lower than those in the control group（ P 〈0. 001）, the time of diuresis stage appeared and urine routine turned normal in the therapeutic group were significantly earlier than those the control group（ P 〈0. 001）. The average level of Cr in the therapeutic group were significantly lower than that in the control group （ P 〈0. 005）;The occurrence of stress uncle, the cases of hemodialysis and the inefficiency rate in the therapeutic group were significantly lower than those in the control group, the effective rate and the total effective rate in the therapeutic group were significantly higher than those in the control group （ P 〈0.05）. No severe complication were found in the treatment group. Conclusion Rhubarb is effective and safe in treatment of ARF caused by head injury.