来氟米特对系统性红斑狼疮治疗前后外周血IL-2R表达变化的临床意义

The Clinical Significace of IL-2R Expres in SLE Patiots before and after the Treatment with Leflunomide

目的探讨系统性红斑狼疮(SLE)患者应用来氟米特(LEF)治疗前后外周血淋巴细胞白介素-2受体(IL-2R)表达变化的临床意义。方法采用SPA免疫酶联法测定了19例活动性SLE患者IL-2R表达,并观察LEF治疗前后IL-2R表达的变化。结果SLE患者活动期IL-2R表达高于正常对照组(P<0.01),LEF治疗后狼疮活动控制达临床缓解的患者,IL-2R表达明显下降(P<0.05),但仍高于正常对照组(P<0.05),其中2例患者治疗后出现IL-2R表达低于正常,出现严重感染。结论外周血淋巴细胞IL-2R表达的检测对SLE活动的判定有一定意义,并可作为LEF疗效判定及指导用药的免疫指标之一。

Objective To explore the clinical significance of peripheral serum interleukin-2 receptor（IL-2R） express in systemic lupus erythematosus（SLE） patients before and after the leflunomide（LEF） treatment. Methods The IL-2R express level in 19 active SLE patients and 20 healthy donor was measured by SPA, and analysis the changes of IL-2R express before and after the LEF treatment. Results The IL-2R express in active SLE patients was apparently higher than that in the control group（ P 〈 0.01 ）. The IL-2R express significantly decreased in the patients who got remission by the LEF treatment （ P 〈 0.05） ,but still higher than that of the control group（ P 〈 0.05） ,in which 2 cases the IL-2R express lower than those of the control group after the LEF treatment, got serious inflection. Conclusion The examination of IL-2R is benefit to the determine of SLE active stage,and is an effective index to determine the curative effects of LEF and to guide the drugs usage.