功能磁共振成像在邻近脑功能区胶质瘤手术前后的应用研究

Application Research of Functional MRI in Pre-and Post-Operationon Patients With Glioma Near Motion Function Area

目的:研究功能磁共振成像(fMRI)对指运动时的功能定位及正常和病理状态下运动皮层的功能变化。探讨其在胶质瘤手术前后的临床应用价值。方法:采用磁共振血氧依赖水平(BILD)原理对20例正常志愿者及40例胶质瘤患者进行脑功能成像,原始数据采集后传入工作站,应用工作站的Functool软件进行图像分析后处理。结果:20例正常志愿者MRI及fMRI图像清晰,脑功能激活区显示良好。40例胶质瘤患者病变侧的功能区出现不同程度的减弱、分散,甚至消失。胶质瘤位置、形态、大小及功能改变的关系能得到清晰显示。结论:fMRI对邻近脑运动功能区胶质瘤患者手术前后的综合评价具有重要临床意义,有利于在肿瘤最大限度切除的前提下尽可能地保留邻近的脑运动功能区。

Objective Study the functional localization of functional magnetic resonance imaging （fMRI） with fingers touch and functional changes of motor cortex in normal or pathologic state so as to explore clinical application of fMRIon pre-and post-gliomas surgery. Methods Applying principle of blood oxygenation level dependent （BILD）, 20 healthy volunteers and 40 patients with intracerebal gliomas underwent fMRI in motion function area. After the initial data acquisition introduced into workstation, image analysis was performed with the use of Functool software. Results The im- age of MRI and fMRI for 20 healthy volunteers were clear with good activation in brain motion function area. While the pathological changes domain in 40 patients with gliomas showed weaken, dispersion at different degree or even disappeared. Location, appearance, size and functional change displayed clearly. Conclusions Comprehensive evaluation of fMRI in pre-and post-operation on patients with glioma near motion function area is of important clinical significance. It helps to reserve more functional area near glioma on the hypothesis of utmost tumor ablation.