148例MDS患者实验室检查结果分析

The Laboratory Examine Instance Analyse of 148 Cases Patient with Myelodysplastic Syndrome

目的:提高骨髓增生异常综合征(MDS)的实验室诊断水平及规范性。方法:回顾分析了148例MDS患者的实验室检测方法及其细胞形态学变化特征。结果:外周血检查、骨髓检查、免疫组化染色及骨髓活检等方法所显示的病态造血表现均不同,与MDS分型、分期有直接关系,MDS的诊断除实验室检查外,必须结合临床表现。结论:MDS的诊断要结合临床表现。在病态造血中以小巨核细胞、pelger畸形具有诊断意义,在外周血片中仔细寻找原始细胞及淋巴样小巨核细胞,对诊断有特殊意义。

Objective To advance laboratory diagnose level and criterion character of myelodysplastic syndrome （MDS）. Methods Review analyze laboratory examine methods and the cell morphologic variety character of 148 cases patient with MDS. Results The methods of around blood checking, marrow checking, immunity tissue-chymistdyeing andmarrow living tissue checking showed that their result of morbidity hematopoietic represent was distinctness, they related with type and stage of MDS. The diagnosis of MDS must combined with clinic represent except of laborstory checking. Conclusion The diagnosis of MDS must combined with clinic represent. The small huge-nucleus cell and pelger catface have diagnosis meaning in the morbidity hematopoiesis,and the originality cell and lymph-type small huge-nucleus cell have special meaning for diagnosis of MDS in around blood patch.