乙酰胺救治重度氟乙酰胺中毒55例疗效观察

The Curative Effect Observation of Acetamide Cure 55 Cases Patients with Scale Degree Fluorin Acetamide Poisoning

目的:为提高重度氟乙酰胺中毒的抢救成功率,降低病死率,探索更有效的治疗方案。方法:早期采用大剂量乙酰胺0.5g/kg^2.0g/kg加入5%~10%葡萄糖注射液内静脉滴注2次/d^4次/d。结果:治疗组55例重度中毒患者治愈53例,治愈率96.4%;死亡2例,占3.6%。对照组30例,治愈22例,治愈率73.3%;死亡6例,占20%;后遗症2例,占6.7%。两组差异有显著性,P<0.01。结论:大剂量乙酰胺静脉滴注可提高氟乙酰胺中毒的抢救成功率,避免了肌注局部刺激作用,效果较好。

Objective To improve the successful rates of salvage of patients with fluorin acetamide poisoning, reduce the death rates,explore the more effective treatment projects. Methods Used 5%-10% glucose injection and added great dose of acetamide 0.5 g/kg-2.0 g/kg ,injected into the vein of the poisoning patients （2-4 ）times a day in the early period. Resultes 55 cases patients of the treatments group with scale degree poisoning of fluorin acetamide, thecure rates were 96.4% ,2 cases were death,occupy 3.6%. 30 cases were the contrast group,there were 22 cases of this group were cured,the cure rates were 73.3% ,6 cases were death,occupy 20% ,2 cases were sequela, occupy 6. 7%. Two groups had a notable difference, P〈0. 01. Conclusions Use great dose of acetamide can improve the successful rates of salvage, it can avoid the local stimulation effect of injection, has better effect.