p63基因在食管鳞癌组织中的表达

The expression of the p63 gene in the esophageal squamous-cell carcinoma

目的:研究p63基因在食管癌和贲门癌组织中的表达情况。方法:应用免疫组织化学SP法检测贲门癌和食管癌p63基因蛋白的表达。结果:食管癌组织中p63表达阳性率为96.7%(29/30),贲门癌组织中p63基因蛋白免疫阳性表达率为10.4%(3/28),二者差异极显著(P<0.001)。在食管鳞癌组织中p63基因蛋白表达强度与癌组织的分化程度呈负相关(r=-0.383),与肿瘤的浸润呈正相关(r=0.577),与淋巴转移呈正相关(r=0.549),与年龄和性别无关(P>0.05)。结论:p63基因在食管鳞癌组织中呈高表达,表明可能参与致癌作用,而在贲门腺癌中的作用不明显,提示二者在发病的机理上可能存在差异。

Objective ：To study the expression of the p63 gene in the esophageal and cardiac carcinoma. Methods： Immunohistochemical methods（SP） was used to determine the immunoreactivity of p63 genes protein in esophageal squamous -cell carcinoma and cardiac adenocarcinoma. Results： p63 genses protein expressed in the esophageal squamous- cell carcinoma tissue（96. 7% ） which was significantily higher than cardia adenocarcinoma tissue （10.4%）. The expression of p63 genes protein was related with the diffentiation and invation of the carcinoma , and lymph node metastasis, but not correlated with the age and sex. Conclusion： The p63 gene is high expressed in esophageal squamous - cell, maybe an oncogene in the formation of the esophageal squamous carcinanoma , but not in cardiac adenocarcinoma , that may show the differences in molecule mechanism.