非小细胞肺癌同步放化疗与单纯放疗的疗效比较

Analysis of the curative effect of concomitant radiochemotherapy and radiotherapy alone for stage Ⅲ non-small cell lung cancer

目的:研究同步放、化疗对不能手术的Ⅲ期非小细胞肺癌的疗效及毒副反应。方法:76例Ⅲ期不能手术的非小细胞肺癌患者被随机分成同步放化疗组(同步组)和单纯放疗组(单放组),两组病例均给予6MV-X线,常规分割放疗,每次2Gy,每周5次,肿瘤灶总剂量为DT60Gy^70Gy,同步组在放疗同时给予足叶乙甙、顺铂化疗。结果:同步组和单放组的有效率分别是79.0%和60.5%,无显著性差异(P>0.05),两组的完全缓解率分别是31.6%和10.5%,同步组明显高于单放组(P<0.05)。同步组1年生存率明显高于单放组(P<0.05),分别为57.9%和31.6%,同步组毒副反应主要是Ⅰ,Ⅱ度骨髓抑制和消化道反应。结论:同步放、化疗对不能手术的Ⅲ期非小细胞肺癌有较好的疗效,值得进一步临床研究。

Objectlve：To evaluate the efficacy and toxicity of concomitant radiochemotherapy （CRCT） for unresectable stage Ⅲ non -small cell lung cancer （NSCLC）. Methods： Seventy six patients with unresectable stage Ⅲ NSCLC were clivided randomizly into concomitant radiochemotherapy group （ CRCT group） and mere radiotherapy group （ RT group）. The method of radiotherapy was the same in the two groups patients in conventional fractionation received 2.0 Gy/per fraction , five fractions a week , the total planned radiation dose was 60 - 70 Gy in tumour. But the patients of CRCT group received chemotherapy （ c,splatin and etoposide） concomitant with the radiotherapy. Results ：The overall response rates for CRCT group and RT group were 79.0% and 60.5% respectively （ P 〉 0.05 ）, and their complete response rates were 31.6% and 10.5 % respectively （ P 〈 0.05 ）, and 1 - year survival rates were 57.9% and 31.6% ,there was a significant difference in the complete response rates and 1 - year survival rates between two groups （ P 〈 0.05 ）. The major toxicity of CRCT group were gastroin - testinal tract reaction and myelosuppression. Conclusion： The conco - mitant radiochemotherapy is effective on treatment of patients with unresectable stage Ⅲ non -small cell lung cancer.