人大肠腺癌中MMP-9与bFGF的表达及意义

Expressions and significances of MMP-9 and bFGF in human colorectal adenocarcinoma

目的:探讨大肠腺癌中MMP-9、bFGF的表达及其与大肠腺癌浸润转移的关系。方法:采用免疫组化SP法,检测66例大肠腺癌、31例大肠腺瘤及21例正常大肠粘膜中MMP-9、bFGF的表达情况。结果:66例大肠腺癌中MMP-9、bFGF的阳性表达率分别为79%、59%,二者的表达与大肠腺癌的浸润深度有密切关系(P<0.05),二者在大肠腺癌中的表达呈正相关关系(γ=0.548,P=0.00)。结论:MMP-9、bFGF与大肠腺癌的浸润转移密切相关,有望成为判断大肠腺癌浸润转移恶性生物学行为的有价值的指标。

Objective： To study the expressions and significances of matrix metalloproteinases - 9 （ MMP - 9 ） and bFGF in human colorectal adenocarcinoma. Methods ：The expressions of MMP -9 and bFGF in human colorectal adenocarcinoma were tested by immunochemical S - P method. Results：The positive rates of MMP -9 and bFGF in human colorectal adenocarcinoma were 79% and 59%. The expressions of MMP - 9 and bFGF in human colorectal adenocarcinoma were related to the infiltrating depth of cancer cells （ P 〈 0. 05 ）. There was positive correlation between MMP - 9 and bFGF （ γ= 0. 548, P = 0. 00）. Conclusion： The expressions of MMP - 9 and bFGF are significantly correiated with invasion and metastasis of colorectal adenocarcinoma, which might be an index to evaluate tumor invasion and metastasis.