旋覆代赭汤加减治疗化疗诱发的顽固性呃逆

Effect of modified Xuanfu Daizhe Decoction in treating intractable singultus induced by chemotherapy

目的：观察旋覆代赭汤加减治疗化疗诱发的顽固性呃逆的临床疗效和毒性反应。方法：采用旋覆代赭汤加减治疗21例化疗诱发的顽固性呃逆。结果：21例患者经旋覆代赭汤加减治疗1～2个疗程后，顽固性呃逆全部缓解14例，部分缓解5例，无缓解2例，起效时间（1～5）天，平均2．6天达到部分缓解，3．8天达到全部缓解。全组病例未见明显毒性反应。结论：旋覆代赭汤加减可以有效治疗化疗诱发的顽固性呃逆，避免大剂量胃复安引起的毒性反应。

Objective：To assess the therapeutic effect and toxicity of modified Xuanfu Daizhe Decoction in treating intractable singultus induced by chemotherapy（ISIBC）. Methods： The patients took orally modified Xuanfu Daizhe Decoction to treat ISIBC. Results： After treatment of one to two cycles, in 22 patients the complete respose occurred in fourteen cases and partial respose five cases, two cases no changed. The respose time was from one to five days after treatment, mean time of appearing partial respose was 2.6 days, and complete respose was 3.8 days. All patients did not occur obvious toxicity. Conclusion： Modified Xuanfu Daizhe Decoction was effective to ISIBC, and might avoid serious toxicity induced by high -dose Paspertin .