男性血液透析患者性激素水平的变化

Study of sex hormone level in male hemodialysis patients

目的观察男性血液透析患者的血清性激素水平的变化。方法观察上海市第一人民医院3组人群:血液透析组、对照组、移植组。记录3组的年龄并测定血清性激素的水平,进行分析。结果血液透析组的血清FSH、LH、PRL、E2、P水平显著高于对照组和移植组,T水平显著低于对照组。血液透析组的血清T水平低于移植组,差异无显著性。对照组和移植组的性激素水平差异无显著性。结论在男性血液透析患者中存在着下丘脑-垂体-性腺轴的紊乱,血清FSH、LH、PRL、P、E2水平的明显增高,血清T水平的明显下降。肾移植可以纠正慢性肾衰竭血液透析患者的性激素水平的紊乱。

Objective To investigate the sex hormone level in male hemodialysis patients, Methods Were three groups observed：HD group, control group and transplantation group, their age were obserred and the sex hormone level were detected. Results The levels of FSH. LH. PRL. E2. P in HD group were significant higher than that in the control group and transplantation group, the T level was significantly lower in HD group than that in the control group. There were no significant difference of sex hormone level between control group and transplantation group. Condusion There is hypothalamic-pituitary-gonadal axis disorder in mole hemodialysis patients： Their FSH. LH. E2. PRL. P level increase significantly, and the T level decrease significanlty. Renal transplantation may reverse the abnormal of the hypothalamic-pituitary-gonadal axis.