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肿瘤中胰岛素样生长因子Ⅱ基因印记及其丢失的机制 被引量：3

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摘要 基因组印记(genomic imprinting)是目前肿瘤医学领域研究的新热点,印记基因胰岛素样生长因子Ⅱ基因(insulin-like growth factor 2, IGF2)与肿瘤相关性的研究也逐渐显现其参与肿瘤的发生、发展过程．IGF2是最早发现的印记基因之一,对个体的生长发育起着重要的作用．近年发现大多数恶性肿瘤中都存在该基因的印记丢失所致的IGF2高表达现象,且IGF2印记丢失可以作为大肠癌等肿瘤发生危险性的分子标记,但肿瘤中IGF2印记形成和丢失的机制尚不清楚,本文将从等位基因差异性甲基化区域(differentially methylated region, DMR)甲基化状态、绝缘蛋白CTCF(CCCTC- binding factor)结合能力及BORIS(brother of the regulator of imprinted sites)共同参与印记形成几个方面,阐述肿瘤中IGF2印记形成及其印记丢失的可能机制．
作者 樊红 徐卫芳
机构地区 东南大学"发育与疾病相关基因"教育部重点实验室东南大学医学院遗传与发育生物学系
出处 《世界华人消化杂志》 CAS 北大核心 2006年第23期2324-2328,共5页 World Chinese Journal of Digestology
基金 江苏省自然科学基金.No.BK2002054 国家自然科学基金 No.30470950
关键词 印记基因 DMR LOI CTCF
分类号 R730.2 [医药卫生—肿瘤]
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世界华人消化杂志
2006年 第23期

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