脊髓损伤修复的方法学进展

Repair of spinal cord injury:advancement in methods

传统观念认为,脊髓损伤后由于神经元不能再生而不能修复。但近年来的基础研究结果证明,中枢轴突损伤后在一定条件下是可以再生的,几个里程碑式的研究带来了令人鼓舞的结果。这些研究涉及到器官水平、细胞水平和分子水平的修复。目前神经科学界已经达成广泛共识:脊髓损伤最终是可以修复的,但既往研究尚存在实验设计上的缺陷、实验结果不能很好的重复等问题。本文介绍了国内外有关脊髓损伤修复的方法学研究进展,为今后脊髓损伤修复的研究提供参考。

Traditionally, spinal cord injuries are conceived unrepairable because the injured neurons can not regenerate. However, recent studies proved that axons of the central nerves system could regenerate under some specified conditions. Inspiring results had been obtained in several milestone researches at organ, cell and molecule levels. Currently a consensus has been reached in the neurology circle that spinal cord injuries are repairable, but the past studies had shortcomings such as defective experiment designing and unsatisfactory repeatability. This article reviews the advance in the repair methods of spinal cord injury, providing reference for future studies.