摘要
2型糖尿病(T2DM)家系中糖耐量正常的一级亲属在发生糖代谢异常前,往往已存在脂代谢紊乱;而其与胰岛素抵抗、脂代谢中关键酶的活性改变、脂联素水平下降以及家系中某些遗传易感性相关;并可加速T2DM的发生和发展,同时增加心血管疾病的发生率。因此及早筛查这些脂代谢异常者并给予积极干预和治疗具有重要的临床意义。
The normoglycemic first-degree relatives of type 2 diabetes mellitus（T2DM） are already associated with dyslipidemia before glucose intolerance. The insulin resistance, the change of key enzyme in the lipid mebabolism, the decrease of adiponectin and the genetic predisposition are associated with the dyslipidemia. The dyslipidemia accelerates the progress of T2DM and increases the incidence rate of cardiovascular diseases. In this way, the screening of the dyslipidemic relatives and the intervention and treatment will postpone the development of T2DM and reduce the incidence rate of cardiovascular diseases.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2006年第9期1002-1005,共4页
Journal of Shanghai Jiao tong University:Medical Science
基金
上海交通大学医学院自然科学基金(02XJ21016)资助项目
关键词
2型糖尿病
一级亲属
胰岛素抵抗
脂蛋白脂酶
脂联素
遗传易感性
type 2 diabetes mellitus
first-degree relatives
insulin resistance
lipoprotein lipaseadiponectin
genetic predisposition
