多部位鲍温样丘疹病1例

A Case of Multi-location Bowenoid Papulosis

目的报告1例少见的多部位鲍温样丘疹病。方法对其临床、血液免疫学检查、皮肤组织病理进行分析研究。结果RPR及TPPA皆(-);HPV-DNA原位杂交:16/18、31/33型皆(-)。组织病理示表皮角化不全,假上皮瘤样增生,棘层肥厚;棘层细胞大小不等、排列紊乱,细胞核异形、深染;可见核分裂象及角化不良细胞;真皮浅层少量淋巴细胞浸润;阴茎部皮损中棘细胞大小不等、排列紊乱明显,凹空细胞数量少,而肛周皮损中可见大量凹空细胞及较多的角化不良细胞。结论该病可能是HPV16、18、31、33以外型别致病,同时具有的尖锐湿疣病理改变,颇为特殊。

A rare case of multi-locaion bowenoid papulosis was reported.Methods： the patient＇s clinical features and histopathological changes were analyzed possible etiological factors were examined.Results rapid plasma regain lest（RPR）and treponema pallidum particle agglutimation test （TPPA）are negative ,human papilloma virns （HPV） type 16,18,31 and 33DNA are undetected by in situ hybridlzation with digoxin labeled probes.histologically,epidermis showed parakeatosis ,acanthosis,pseudoepitheliomatous hyperplassia;spinous cell were disorder and various in size mitoses and byskeratosis cells were present .The upper dermis had a mild lymphocytic infiltrate .In penis lesion ,the disorder and verious keralocyte were more distinct .whereas in perianal lesion ,vacuoler cells and dyskeratosis cells were abundantly present .Conclusion the case is unusual in its histopathological changes which had charaoteristic of condyloma acuminatum and may caused by other types of HPV execpt type 16,18,21,33.