斯皮茨痣16例临床及组织病理分析

Clinical and histopathological analysis of 16 cases of Spitz nevus

目的:分析斯皮茨痣(Spitznevus)的临床及组织病理特点。方法:采用回顾性分析对16例斯皮茨痣患者的临床及组织病理资料进行分析。结果:16例斯皮茨痣多发生于头面部和四肢,主要表现为黑色丘疹或斑疹,临床上容易误诊为色素痣。大部分斯皮茨痣具有良性肿瘤的特点,少数斯皮茨痣结构呈不对称性或细胞具有异形性,组织病理改变结合临床资料分析是诊断的关键。结论:表皮和附属器增生可作为斯皮茨痣与黑素瘤鉴别的依据之一,国人斯皮茨痣Kamino小体较少见。

Objective： To evaluate the clinical and histopathological data of Spitz nevus. Methods： A retrospective analysis of 16 cases of Spitz nevus was carried out. Results： The most frequent anatomical location of Spitz nevus was the head and extremities. Spitz nevus always presented as black papules and maeulae and was easy to be misdiagnosed as common nevus. Histopathologieally, most of these Spitz nevus had the characteristics of benign tumor, and rare cases were asymmetric or had cytological atypia. It was important to make a correct diagnosis based on histopathologieal and clinical data. Conclusion： Hyperplasia of epidermis and appendix should be considered as a clue to differentiate Spitz nevus from melanoma. Kamino body was rare in Chinese cases.