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早期2型糖尿病患者运动时骨骼肌氧代谢及外周血管功能变化 被引量：1

Muscle Oxygen Supply and Consumption, and Peripheral Arterial Function in Patients with Early Type 2 Diabetes Mellitus during Exercise
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摘要 目的:探讨早期2型糖尿病患者运动时骨骼肌氧代谢水平及外周血管功能变化。方法:采用近红外光谱(NIRS)测定技术,对34例早期2型糖尿病患者(糖尿病组)和9例正常人(对照组)足底屈运动时及运动结束后的腓肠肌氧合血红蛋白/肌红蛋白(OxyHb/Mb)的含量进行测定,并结合踝肱指数(ABPI)、四肢脉波速度(baPWV)等外周血管功能指标进行分析。结果:糖尿病组骨骼肌氧利用率(MO2)明显低于对照组(P<0.001),OxyHb/Mb的恢复时间(Tr)为15.9±9.6sec,与对照组10.2±4.5sec比较有延长趋势。糖尿病组ABPI为1.15±0.06,与对照组1.16±0.07比较无明显差异;糖尿病组baPWV为1520.2±211.8cm/sec,明显低于对照组1358.0±169.3cm/sec(P<0.05)。提示早期2型糖尿病患者骨骼肌氧利用降低。 Purpose To analyze and explore the skeletal muscle oxygen supply and oxygen consumption, and the change in peripheral arterial function in patients with early type 2 diabetes mellitus during exercise. Methods Near infrared spectroscopy （NIRS） was adopted to observe the changes in content of oxygenated hemoglobin/mymoglobin（OxyHb/Mb） of gastrocnemius during and after ankle plantar flexion exercise in 34 patients with early type 2 diabetes mellitus and 9 age - matched healthy volunteer. OxyHb/Mb in combination with peripheral arterial function indexes, such as the ankle brachial pressure index （ABPI） and brachial ankle pulse wave velocity （baPWV） were analyzed and compared. Results Oxygen utilization rate of skeletal muscle （MO2） in diabetic group is significantly lower than that in control group （P 〈 0.001 ）, and the recovery time （Tr） of OxyHb/Mb in diabetic group is 15.9 ± 9.6sec with somewhat longer than that in control group （10.2 ± 4.5sec）. The ABPI of the diabetic group and control group are 1.15 ± 0.06, and 1.16 ± 0.07, respectively. The baPWV in diabetic group （1520.2 ± 211 .Scm/sec） is significantly lower than that in control group （1358.0 ± 169.3cm/sec） （P 〈 0.05）. Conclusion Oxygen consumption in skeletal muscle of patients with early type 2 diabetes mellitus during exercise are reduced.
作者 刘殿玉 刘晓燕 王国祥
机构地区 苏州大学体育学院 北京世纪坛医院
出处 《中国运动医学杂志》 CAS CSCD 北大核心 2006年第5期527-529,546,共4页 Chinese Journal of Sports Medicine
关键词 2型糖尿病 肌氧含量 外周血管功能 diabetes, muscle oxygen content, peripheral arterial function
分类号 R87 [医药卫生—运动医学] R587.1 [医药卫生—内分泌]
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参考文献9

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共引文献12

同被引文献17

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中国运动医学杂志
2006年 第5期

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