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颈动脉内膜切除术后细胞凋亡对早期再狭窄的影响 被引量：3

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摘要 目的探讨颈动脉内膜切除术(CEA)后新内膜形成过程中细胞凋亡对早期再狭窄的影响。方法以新西兰兔颈动脉粥样硬化性狭窄动物模型为基础,分别采用免疫组织化学方法及原位末端标记(TUNEL)法观察颈动脉内膜切除术后不同时间点新内膜中Bax、Bcl-2动态表达及细胞凋亡的过程。结果Bax、Bcl-2在正常动脉壁无表达。Bcl-2于术后3 d内膜开始表达,术后30 d达到高峰,随后逐渐下降。Bax于术后3 d内膜开始表达。术后7 d到达高峰,随后逐渐下降,Bcl-2/Bax的比值在术后30 d达峰值。新内膜中细胞凋亡则在早期再狭窄的后期90 d达峰值。结论新内膜中细胞凋亡处于较活跃的水平,细胞凋亡在CEA术后早期再狭窄形成过程中有重要作用。
作者 梁春阳 周定标 余新光 许百男 章文斌 王世波
机构地区 中国人民解放军总医院神经外科
出处 《中华显微外科杂志》 CSCD 北大核心 2006年第5期367-368,共2页 Chinese Journal of Microsurgery
基金 "十五"国家科技攻关计划重大疾病防治研究项目资助课题(2001BA703B16)
关键词 颈动脉内膜切除术 再狭窄 细胞凋亡
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献6

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共引文献51

同被引文献53

  • 1梁春阳,周定标,余新光,许百男,章文斌,王世波.ICAM-1、MMP-2基因在颈动脉内膜切除术后早期再狭窄中的动态表达[J].中华神经外科杂志,2007,23(3):220-223. 被引量：2
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引证文献3

二级引证文献5

中华显微外科杂志
2006年 第5期

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