胎盘促肾上腺皮质激素释放激素研究进展

PLACENAL CORTICOTROPIN-RELEASING HORMONE

回顾了关于胎盘促肾上腺皮质激素释放激素 (pCRH)研究的最新进展 .其内容包括 pCRH的合成与分泌、pCRH释放的调节、孕妇血浆CRH水平的变化及其对HPA轴活动的影响以及pCRH的生物学作用等 .作者认为 ,进一步阐明 pCRH的旁分泌、自分泌和长距分泌作用将助于理解妊娠维持。

Some recent progresses in the research of placental corticotropin_releasing hormone (pCRH) were reviewed,including synthesis and secretion of pCRH,regulation of pCRH release,changes of plasma CRH levels in pregnant women and its effects on hypothalanus_pituitary_adrenal axis function and the biological role of pCRH.The auther believes that further study for the autocrine,paracrine and telecrine role of pCRH will conduce to the understanding of physiological mechanism of pregnancy maintenance,fetus development and parturition initiation.