水蛭微粉对急性脑梗塞患者血液vWF、GMP-140的影响

Effect of vWF,GMP-140 of ultra-fine particle of leeches in treating acute brain infarction disease

目的:探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理。方法:63例脑梗塞患者(病程在3 d以内)随机分为3组。A组(对照组):21例,常规西药治疗;B组(粗粉组):21例,常规西药加水蛭粗粉治疗;C组(微粉组):21例,常规西药加水蛭微粉治疗。观察脑梗塞患者的临床治疗效果,治疗前后的血液血管性假血友病因子(vWF),血小板α-颗粒膜蛋白140(GMP-140、CD62p)水平。结果:两种水蛭制剂均能提高脑梗塞患者临床疗效,以微粉组疗效明显,总有效率比较:B组优于A组,P<0.05;C组优于A组,P<0.01。愈显率比较:C组优于B组,P<0.05。3组患者上述两项实验指标治疗后也均有改善,两水蛭组优于对照组,P<0.01,C组优于B组,P<0.01。结论:水蛭微粉较水蛭粗粉更能有效地提高脑梗塞患者的临床疗效,更能有效地抑制血管内皮损伤、血小板活化。

Objective： To estimate the value of ultra-fine particle of Leeches on acute brain infarction disease. Methods： A total of 63 cases of early brain infarction disease were divided into 3 groups： group A, treated with normal medicine; group B, treated with normal medicine and bigger particle of Leeches;group C , treated with normal medicine and ultra-fine particle of Leeches. The clinical symptom before and after treatment was observed, and also the level of blood Von Wille brand factor（vWF）, p-selection（GMP-140） were observed. Results： The total response rate of group C and B was higher than that of group A（ P 〈 0.01, 0.05）. The curative and marked response rates of group C were higher than those of group B（ P 〈 0.05）. The improvement of blood vWF, GMP-140 of group C was better than that of group B（ P 〈 0.05,0.01） ; and that of group B was better than group A（ P 〈 0.05, 0.01）. Conclusion： There are serious vascular endothelium injury, platelet activity in both brain infarction patients. Ultra-fine particle of Leeches is more effective in treating brain infarction disease than bigger particle of Leeches, and it is more effective in improving the blood levels of vWF, GMP-140.