摘要
目的:了解冠心病患者经皮冠状动脉内介入治疗(percutaneous coronary intervention,PCI)围手术期血管内皮生化标志物内皮素_1(endothelin_1,ET_1)、一氧化氮(nitric oxide,NO)的变化,探讨他汀类药物预处理是否能够减弱围手术期血管内皮的急性损伤。方法:选择具有典型稳定性心绞痛症状或负荷试验阳性患者101例,采用随机、对照、单盲的方法将病人分为两组:对照组49例给予安慰剂治疗,他汀组52例给予辛伐他汀片20 mg,每晚睡前服用。所有病人入选后按分组开始治疗,治疗7 d后行PCI治疗,术前、术后8 h、术后24 h分别检测内皮素_1、NO。结果:两组PCI术前ET_1、NO比较无统计学意义,P>0.05;两组术后8 h与术前比较,ET_1明显升高,NO明显降低,P<0.05,术后24 h,ET_1、NO恢复至术前水平;术后8 h,常规组ET_1较他汀组升高明显,NO较他汀组降低明显,P<0.05。结论:PCI围手术期存在血管内皮的急性损伤,辛伐他汀预处理具有明显改善围手术期血管内皮急性损伤作用。
Objective ： To know the changes of endothelial function during elective pereutaneous coronary intervention（PCI）and to investigate whether to weaken the changes with simvastatin therapy before PCI. Methods ： 101 patients with chronic stable angina without previous statin treatment were enrolled in the study. Patients scheduled for elective coronary intervention were randomized to simvastatin （20 mg/d, n = 52）or placebo （ n = 49） 7 days before the procedure. Endothelin-1 （ET-1）and nitric oxide （NO） levels were measured at baseline and at 8 and 24 hours after the procedure. Results ： After pretreatment, The serum levels of ET-1 and NO were similar between various groups before PCI, P 〉 0.05; At 8 hours, ET-1 levels of two groups were more significantly increased and NO levels were more significantly decreased than at baseline, P 〈 0.05, moreover, the changes of ET-1 and NO were more marked in the control group compared with the statin group, P 〈 0.05; at 24 hours, these changes were disappeared. Conclusion ： During PCI endothelial function were damaged. Pretreatment with sim- vastatin 20 mg/d for 7 days can significantly reduces periprocedural endothelial function injury in elective PCI.
出处
《河南医学研究》
CAS
2006年第3期229-231,共3页
Henan Medical Research
