期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TLR4在内毒素导致组织损伤过程中的信号转导作用

Signal transduction effection of TLR4 on tissue injury induced by endotoxin
下载PDF
导出
作者 樊香 王怀立（审校）
机构地区 郑州大学第一附属医院儿科 郑州大学第一附属医院儿科
出处 《河南医学研究》 CAS 2006年第3期272-276,共5页 Henan Medical Research
关键词 信号转导作用 内毒素 损伤过程 TLR4 脂多糖结合蛋白 CD14分子 PROTEIN NF-ΚB激活
分类号 R735.702 [医药卫生—肿瘤]
  • 相关文献

参考文献29

  • 1Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A Human homologue of the Drosophila Toll protein signals activation of adaptive immunity[ J]. Nature, 1997,388 (6640) : 394-397.
  • 2Qureshi ST, Lariviere L, Leveque G, et al. Endotoxin-ToIerant mice have mutation in Toll-like receptor 4 (Tlt4)[J] .J Exp Med, 1999, 189(4):615-625.
  • 3Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge:Toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to Iipopolysaccharide:evidence for TLR4 as the Lps gene product[J] .J Immunol, 1999, 162(7) :3749-3752.
  • 4Pohorak A, Smirnova I, He X, et al. Genetic and physical Mapping of the LPS locus : identification of the toll-4 receptor as a candidate gene in thecritical region[ J ]. Blood Cells Mol Dis, 1998,24(3 ) : 340-355.
  • 5Janeway CA Jr, Medzhitov R. Introduction : the role of innate immunity in the adaptive immune response[ J]. Semin Immunol, 1998,10(5):349-350.
  • 6Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutation on TLr4 gene [ J ]. Science, 1998,282(5396) : 2085-2088.
  • 7Seija Lehnardt, Leon Massillon. Activation of innate immunity in the CNS tiggers neurodegeneration through a Toll-like receptor--4-dependent pathway[J]. Prac Natl Acad Sd USA,2003,8,100(14) :8514-8519.
  • 8Goralski KB, Abdulla D.Toll-like receptor-4 regulation of hepatic Cyp3all metaboIism in a mouse model of LPS-induced CNS inflammation[J] .Am J Physiol Gastrointest Liver Physiol, 2005,289 ( 3 ) :G434-443.
  • 9Aderen A, Uleritch RJ.Toll-like receptorsi in the induction of the innate immune response [ J ]. Nature, 2000,406 ( 6797 ) : 782-787.
  • 10Wurfel MM, MonksBG, Ingalls RR, et al.Targeted Deletion of the Lipopolysaccha- ride-binding protein gene leads to profound sup pression of receptors ex vivo, Whereas in Vivo responses Remain intact[ J ]. J Exp Med, 1997,186(12) :2051-2056.

二级参考文献18

  • 1Andrem U J. Toll-like receptors in the induction of the innate immune response. Nature ,2000,406(17) :782-787.
  • 2Sugama S, Kim Y,Baker H, et al. Tissue-specific expression of rat IL-18 gene response to andrenocorticotropic hormone tretment. J. Immun, 2000,165 ( 11 ) : 6278 - 6292.
  • 3Franz S, Kobzik L, Kim YD,et al. Toll4(TLR4) expression in myocytes in normal and failing myocarcium. J. Clin. Invest,1999,104 : 271-280.
  • 4Swantek JL, Tsen MF, Cobb MH, et al. IL- 1 receptor-association kinase modulates host responsiveness to endotoxin. J Immun,2000,164(8) :4301-4306.
  • 5Laflamme N, Rivest S. Toll-like receptor 4 : the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FESEB J,2001,15(1) :155-163.
  • 6Wenzel R P, Pinsky M R, Ulevitch R J, et al. Current understanding of sepsis[J]. Clin Infect Dis, 1996, 22(3): 407-412.
  • 7Smirnova I, Poltorak A, Chan E K, et al. Phylogenetic variation and polymorphism at the toll-like receptor4 locus(TLR4)[J]. Genome Biol, 2000, 1(1): 1-10.
  • 8Poltorak A, Smirnoval I, He X, et al. Genetic and physical mapping of the LPS locus: identification of the toll-4 receptor as a candidate gene in the critical region[J]. Blood Cells Mol Dis, 1998, 24(3): 340-355.
  • 9Poltorak A, Smirnova I, Clisch R, et al. Limits of a deletion spanning TLR4 in C57BL/10ScCr mice[J]. Endotoxin Res, 2000, 6(1): 51-56.
  • 10Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4(TLR4)- deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product[J]. J Immunol, 1999, 162(7): 3749-3752.

共引文献10

河南医学研究
2006年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部